ICH on Q8, Q9 and Q10 Questions & Answers (R4)提问

jianglinluye

ICH on Q8, Q9 and Q10 Questions & Answers (R4)中  in-line, on-line, at-line 都是什么意思？

jianglinluye

希望大家尽快解答

zysx01234

【求助】in-line, on-line, at-line 有何区别啊？ - 分析技术讨论版 -丁香园论坛
http://www.dxy.cn/bbs/thread/26997807#26997807

zysx01234

谈及检验测试，常见到in-line on-line at-line off-line等不同表述，现将其含义介绍如下：
1.Off-line 离线化验，车间取样后，样品送到本厂的化验室进行检验。
At-line 生产线取样，样品在生产线附近的仪器上化验。常用仪器;天平，酸度计，温度计，硬度计。
例句：(
Sartorius offers a wide range of moisture analysis procedures for at-line / off-line use in the lab and production area.
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At-line: The analysis can be done on samples whICH the operator brings to the analyzer or samples that are taken from the production by a customer existing sampling method. At-line systems are often integrated into robotic laboratories.
Laser diffraction for Laboratory applications (off-line)
Samples taken from the line can be analysed at-line with instruments located the production area. If this is not possible, they can be taken to a QC laboratory for an off-line measurement on-site, or then can be sent to a remote central laboratory for off-site analysis where highly complex, expensive instrumentation is required.
2. On-line/in-line 在线分析。
On-line 分析仪器安装在生产线上，对每个独立的样品进行测量，例如检重秤。
In-line分析仪器安装在生产线某个设备上，对物料进行连续测量，例如纯化水机上的电导计，酸度计，温度计。
例句：3
On-line measurements provide data on a continuous production process that can be used to adjust process variables using feedback or feed-forward control. This requires that the data on a process stream segment are available in “real-time” or with only a short delay after the segment has passed the measuring point.( c4 R1 E: r8 h7 e
On-line measurement can be in-line (the measurement point is in the main process line, or the main process line is accessed through a window or container wall transparent to the radiation in question such as microwave or infra-red). Alternatively, the measuring point can be in a bypass or bleed line. Robotic sampling conditioning and measuring systems connected to the line can also provide a continuous or intermittent input for process control. For batch processes, instruments for in-situ measurements can provide real-time data..

zysx01234

想到了另一组词： in-line, on-line, off-line, at-line ，刚好看到一个图，清楚的解释了这4个的区别，拿来分享一下。
罗嗦一点， 从图中可以看到 On-line,和 In-line 的区别是， On-line直接在反应器里面测量，注意图中反应釜里面有探头（Sensing Head)，是观测真实（化学物理）反应变化的”第一位置“。 也就是 “In situ” 的本意，“in the original or correct place”。 个人理解 On-line，和 In situ没有太大差别，基本可以替换。 一个例句： The measurement takes place directly in-situ without sampling or sample treatment。 In situ中文里有翻译成“原位”的，觉得还算贴切。
In-line 图示在管道里了，不再是original position，这里的环境（比如温度气压）可能就和釜里的不一样了（对化学家来说，条件不同意味反应就不同了， 可能里面某些成分的浓度也不再一样了）。 所以才显得 In Situ的重要。
At-line 必须取样，样品在附近的仪器上化验。
Off-line 离线,必须取样，样品送到其他地方进行检验。
In Situ 在生物学上，还和另2个词有关。比如你做生物核磁分析。
In Vitro : outside the living body and in an artificial enviroment of cells
In Vivo : in the living organism of a an animal or a plant.
源文件可以出自这里 http://www.cvg.ca/Presentations/2007/PAT%20Solution.pdf。

zysx01234

我只是个搬运工

胜利者

好学

jianglinluye

谢谢大家的解答

xqliu

学习了。谢谢解答。

chenjiao501

学习，谢谢分享

Mile1

zysx01234 发表于 2017-5-15 10:25
想到了另一组词： in-line, on-line, off-line, at-line ，刚好看到一个图，清楚的解释了这4个的区别，拿来 ...

这个网址，请问是外网么？

zysx01234

Mile1 发表于 2020-12-17 09:39
这个网址，请问是外网么？

不知道，年数久了，网址可能有改变了。

zackzong

学习中，长知识了

小金库

非常感谢分享