30本关于药物研发和药物化学的书

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[转载]30本关于药物研发和药物化学的书
30本关于药物研发和药物化学的书转载：

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马上就到圣诞元旦了，该为家人、朋友准备礼物了。选什么好呢？如果你的家人、朋友是做药物研究的，有志于在该领域长远发展，不妨给他们送本书，为他们的研究助一臂之力。以下是有着近30年药物研发经验的Derek Lowe博士列出的书籍清单，可以直接点击查看、购买：

药物研发历史：The Evolution of Drug Discovery ，有很多好书从不同层面上讲述了药物研发和疾病治疗的历史，但很少有像这本书这样，从产业的角度上，跟踪、描述了整个药物研发史。

对于普通的药物化学，如果你有Bob Rydzewski的 Real World Drug Discovery: A Chemist's Guide to Biotech and Pharmaceutical Research ，那你现在可以加上 Drug Discovery: Practices, Processes, and Perspectives （编著者Jack Li和E. J. Corey）、Textbook of Drug Design and Discovery（编著者Krogsgaard-Larsen等）、第三版的 The Organic Chemistry of Drug Design and Drug Action ，以及 The Practice of Medicinal Chemistry（Camille Wermuth编著）。为跟上领域发展，一些读者建议阅读Graham Patrick的 An Introduction to Medicinal Chemistry .同样的，Medicinal Chemistry: The Modern Drug Discovery Process 是我认为最近做得很好的入门教材。

工艺化学，推荐Neal Anderson的 Practical Process Research & Development, Repic的 Principles of Process Research and Chemical Development in the Pharmaceutical Industry, Stan Lee和Graham Robinson的 Process Development: Fine Chemicals from Grams to Kilograms, 如果希望水平高一点，可以看McConville的 The Pilot Plant Real Book.

要想寻找以往项目的成功案例，可以在这两本书里找：Rick Ng的 Drugs: From Discovery to Approval, 以及Walter Sneader的 Drug Discovery: A History.

专注于药物研发特定领域的书，Robert Copeland的 Evaluation of Enzyme Inhibitors in Drug Discovery, Brown等人的 Bioisosteres in Medicinal Chemistry, Scaffold Hopping in Medicinal Chemistry, Protein-Protein Interactions in Drug Discovery, Volume 56.

对于那些希望重温生物学的化学家或药剂师，推荐这本现已更新的Terrence Kenakin书的早期版本：A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, 以及 Pharmacology in Drug Discovery: Understanding Drug Response. 还有Cannon的 Pharmacology for Chemists, Nogrady 和Weaver合编的 Molecular Biology in Medicinal Chemistry.

总体而言，大家一致最强烈推荐的书籍之一来自于PK领域——Kerns 和 Di合写的 Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization. 这本书出版于2008年，2015年2月两位作者将出版一本新书：Blood-Brain Barrier in Drug Discovery: Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs. 另外一本以PK为主的书是 Lead Optimization for Medicinal Chemists. 为更好地了解该领域，跟上行业发展步伐，可以看看Donald Birkett的 Pharmacokinetics Made Easy, 以及 Drug Metabolism and Pharmacokinetics Quick Guide.

每一个药物化学家都要学习大量的毒理学知识，非常辛苦。这里有两本书推荐 Casarett & Doull's Toxicology: The Basic Science of Poisons 和 Principles and Methods of Toxicology（Hayes编著）。

最后，还有一本找工作的书也比较有用：Navigating the Path to Industry, 它面向那些正在寻找企业研究职位的学院科学家（不是入门级的人），为他们提供指导。

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TABLE OF CONTENTS Chapter 1 - The Pilot Plant The Role of the Pilot Plant        1-2 Major Factors in Scale-Up        1-3 12 Things to Do During Process Scale-Up        1-6 12 Things to Avoid During Process Scale-Up        1-7 Developing Scalable Reactions        1-8 The Role of Calorimetry and Process Safety Screening        1-11 The Haz-Op        1-12 The Batch Checklist        1-14 The Process Flow Diagram        1-15 The Batch Record        1-16 The Campaign Report        1-17 Notes on GMP        1-18 Chapter 2 - Equipment and Operations The Pilot Plant Equipment Train        2-2 Notes on Equipment Selection, Installation and Maintenance        2-3 Reactors        2-4 Vessel Agitation        2-8 Charging Raw Materials        2-11 Reaction Control        2-13 Sampling for Reaction Monitoring        2-15 Workup        2-16 Partition Coefficient and Extraction Efficiency        2-17 Polish Filtration / Decolorization / Water Removal        2-18 Batch Distillation        2-19 Crystallization        2-21 Product Isolation        2-24 Filtration Scale-Up        2-27 Product Drying        2-29 Scrubbers        2-33 Reactor and Equipment Cleaning        2-34 Chapter 3 - Liquid Handling Introduction and Terminology        3-2 Pump Sizing and Selection        3-4 Pump Installation and Operation        3-5 Rotary Pump Troubleshooting Guide        3-6 Major Pump Types        3-7 Diaphragm Pump Troubleshooting Guide        3-8 Peristaltic Pump Tubing Sizing and Flowrate Guides        3-13 Pipe, Drawn Tube and Fittings        3-14 Flanges and Gaskets        3-19 Valves        3-21 Hose and Hose Fittings        3-23 Liquid Velocity and Pressure Effects        3-24 Viscosity Effects        3-26 Standard O-Ring Size Chart        3-28 Rubber Stopper Sizes        3-29 Ground Glass Joint Sizes        3-29 Capacity of Liquid Storage Tanks        3-30 Storage Drum and Shuttle Data        3-32 Chapter 4 - Heat Transfer Heat Transfer in Stirred Tank Reactors        4-2 Typical Batch Cooling Profiles        4-4 Reactor Heat Transfer Coefficients        4-5 Experimental Determination of Heat Transfer Coefficient        4-7 Heat Exchanger Fundamentals        4-8 Example Heat Exchanger Problem        4-9 Chart for Estimating Log Mean Temperature Difference        4-10 Temperature Control Units        4-11 System Start-up and Operation        4-12 Tips on Using Heat Transfer Fluids in TCUs        4-13 Heat Transfer Fluid Selection        4-14 Specific Heat of Various Heat Transfer Fluids vs. Temperature        4-15 Useful Temperature Ranges and Properties of Commercial HTF 4-16 Notes on the Use of Glycol HTFs        4-18 Specific Gravity of Aqueous Glycol Solutions        4-19 Freezing Points of Aqueous Glycol Solutions        4-20 Boiling Points of Aqueous Glycol Solutions        4-21 Specific Heats of Aqueous Glycol Solutions        4-22 Viscosity of Aqueous Ethylene Glycol Solutions        4-23 Freezing Points of Brines        4-24 Steam Pressure vs. Temperature        4-25 Notes on Process Chillers        4-26 Approximate Chiller Capacity        4-28 Effect of Condenser Cooling Water Temperature        4-28 Chapter 5 - Electricity and Istrumentation Notes on Electrical Safety        5-2 Electric Power Basics        5-3 Wire Data        5-4 Standard Resistor Color Code        5-5 Tips on Making Electrical Connections        5-5 Receptacle Data        5-6 Electrical Enclosure Data        5-7 Hazardous Location Classifications for Electrical Equipment        5-8 Intrinsically Safe Equipment        5-10 Electric Motors        5-11 Motor Nameplate Data        5-11 Typical Current Draw of Induction Motors        5-12 Common Types of Motor Enclosures        5-13 Electric Motor Troubleshooting Guide        5-14 Standard NEMA Motor Frame Sizes        5-14 Temperature Measurement        5-15 The 4-20 mA Transmitter        5-17 Pressure Measurement        5-18 Flow Measurement        5-20 Level Measurement        5-22 pH Measurement and Control        5-24 Notes on Process Control        5-26 Analog vs. Digital Control Networks         5-27 Understanding PID Controllers        5-28 Chapter 6 - Solvents Notes on the Safe Handling of Solvents        6-2 NFPA Solvent Flammability Classifications        6-2 Relative Flammability Hazard of Selected Solvents        6-3 Notes on Solvent Selection        6-4 Some Solvents Useful for Crystallization        6-4 Notes on Solvent Properties Table        6-5 Solvent Properties Table        6-6 Solubility Map of Common Solvents        6-16 Effect of Temperature on Specific Volume        6-17 Enthalpy of Vaporization vs. Boiling Point        6-18 Effect of Temperature on Enthalpy of Vaporization        6-19 Effect of Temperature on Viscosity        6-20 Effect of Temperature on Specific Heat 6-21 Reduced Pressure Boiling Points for Some Common Solvents 6-22 Chart for Estimating Boiling Point vs. Pressure        6-23 Chart for Estimating Vapor Pressure at Elevated Temperatures        6-24 Notes on Distillation and Azeotropes        6-25 Effect of Pressure on Azeotrope Composition        6-26 Water Azeotropes of Some Common Solvents        6-27 Binary Azeotropes of Some Common Solvents        6-28 Ternary Water-Containing Azeotropes of Some Common Solvents        6-40 Solvents Limited for Pharmaceutical Use        6-44 Common Types of Denatured Ethanol        6-44 Important Temperature Dependent Properties of Water        6-45 Common Water Purification Methods        6-47 Process Water Quality Specifications        6-47 Water Conductivity and Resistivity        6-48 Chapter 7 - Compressed Gases Notes on the Safe Handling of Compressed Gases        7-2 Special Precautions for Gaseous Hydrogen        7-3 Precautions for Cryogenic Liquids        7-3 Estimating Partial-Cylinder Contents        7-3 Common Gas Cylinder Types and Specifications        7-4 Typical Gas Cylinder Markings        7-4 Cylinder Valve Outlet Connections for Common Gases        7-6 Recommended Torque Values for CGA Outlet Connections        7-7 CGA Fitting Specifications        7-8 Metering Gases        7-9 Heating Gas Cylinders Safely        7-9 Care and Use of Gas Pressure Regulators        7-10 Physical Properties of Gases        7-11 Properties of Some Cryogenic Liquids        7-12 Gas Leak Detection        7-13 Properties of Air        7-14 Dew Point vs. Relative Humidity        7-15 Compressed Air Systems        7-16 Compressor Horsepower Requirements        7-17 Typical Compressed Air Usage Rates        7-17 Compressed Air Tank Capacity        7-18 Equivalent Cubic Feet of Compressed Air        7-18 Air Flow Through Pipes and Tubes        7-19 Pressure Drop Through Fittings for Air, Steam, or Gases        7-19 Air Flow Through Orifices        7-20 Vacuum Systems        7-21 Chapter 8- Chemical Data Periodic Table of the Elements        8-2 Properties of Commercial Acids and Bases        8-3 pH of Common Acid and Base Solutions        8-3 Recipes for Dilute Acid/Base Solutions        8-4 pKa of Acids, Bases and Buffers        8-6 Properties and Preparation of Buffer Solutions        8-8 Some Useful Buffer Systems        8-9 Some NBS Standardized Buffers        8-9 pH Range of Some Acid-Base Color Indicators        8-9 Aqueous Solubility        8-10 General Water Solubility Rules for Inorganic Compounds        8-10 United States Pharmacopeia Definitions of Solubility        8-10 Aqueous Solubility of Selected Inorganic Compounds        8-11 Aqueous Solubility of Selected Organic Compounds        8-12 Effect of Temperature on Aqueous Solubility of Selected Compounds        8-13 Heat of Solution        8-14 Solution Density        8-15 Density of Selected Aqueous Inorganic Solutions        8-16 SpecificGravity and Density Scales        8-17 Comparison of Various Concentration Scales        8-17 Grades of Chemical Purity        8-18 Drying Agents for Solvents and Solutions        8-18 Names of Ions        8-19 Functional Groups in Organic Chemistry        8-19 Some Common Acronyms Used in Organic Chemistry 8-20 Some Common Types of Organic Reactions        8-21 Chapter 9 - Chemical Safety and Hygiene General Notes on the Safe Handling of Chemicals        9-2 The Chemical Hygiene Plan        9-3 Material Safety Data Sheets        9-4 Classification of Hazardous Substances        9-5 Toxicity and Health        9-6 Fire Safety        9-6 Fire Extinguishers        9-7 Chemical Labeling        9-8 List of Incompatible Chemicals        9-9 Waste Effluent Disposal        9-10 Eye and Face Protection        9-12 Hearing Protection        9-12 Hand Protection        9-13 Glove Selection Guide 9-13 Respiratory Protection        9-16 Chapter 10 - Material Selection Properties of Common Elastomers        10-2 Properties of Common Fluoropolymers        10-3 Properties of Common Plastics        10-4 U.S. Plastics Recycling Symbols        10-4 Properties of Common Metals        10-5 Corrosion        10-6 Relative Corrosion Resistance of Various Materials        10-6 Corrosion Units Conversion Factors        10-7 Galvanic Series of Metals        10-7 Properties and Corrosion of Glass        10-8 Effect of pH on Glass Corrosion Rate        10-8 Substances Know to Attack Borosilicate Glass        10-8 Corrosion of Borosilicate Glass by Acids        10-9 Corrosion of Borosilicate Glass by Bases        10-9 MaterialsCompatibility Table        10-10 Substances Known to Attack 316 Stainless Steel        10-28 Substances Known to Attack Hastelloy C-276        10-28 Substances Known to Attack Tantalum Metal        10-28 Chapter 11 - Miscellaneous Unit Conversion Factors        11-2 Comparison of Unit Systems        11-4 Mathematical and Physical Constants        11-5 Useful Mathematical Relationships        11-5 Exponents and Logarithms        11-5 Polynomials        11-5 Geometric Formulas        11-6 Trigonometry        11-7 Continuous Stirred Tank Dilution Effects (Feed and Bleed)        11-7 Calculations for Asymmetric Crystallizations        11-7 Temperature Conversion Diagram        11-8 Pressure Conversion Diagram        11-9 Vacuum Conversion Diagram        11-10 Useful Cold Mixtures for the Laboratory        11-11 Decimal Equivalents of Fractions of an Inch        11-11 Standard Sieve Specifications        11-12 Mill Grade Wire Cloth Specifications        11-12 Industry-Related Acronyms and Abbreviations        11-13

补充内容 (2015-7-12 22:50):
这本书我有，一位同事分享的（个人觉得很好），但是是否上传，需要经过他的同意！

574859654

英文没学好，看不懂

胜利者

NX的蒲坛

syhorchid

谢谢分享

anson112

真是太好了！

king7566

英文，看不太懂呀