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发表于 2017-1-19 10:39:59
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Laser drilling is well established as an economically viable method for producing sub-millimeter apertures in pharmaceutical tablets. The benefits of sophisticated drug delivery systems are well proven, including decreased dosing frequency, more consistent drug concentration in the blood, and even customized delivery profiles. Osmotic drug delivery systems have proven especially valuable for providing controlled release of medications.
For the manufacturer, laser tablet drilling provides a high speed, highly accurate system that is largely self-operating, and able to visually verify aperture accuracy, even at speeds exceeding 140,000 tablets per hour. The typical aperture in osmotic pump tablets ranges from about 600 μm to 1 mm. Laser drilling, with throughput rates exceeding 140,000 tablets/hour, can easily produce apertures with these necessary dimensional tolerances and cosmetic appearance. As a result, laser drilling is the technology of choice for pharmaceutical tablet production.
Time releasing medication is the most common use for tablet drilling. Tablets or capsules can be made in layers with an indigestible coating, followed by medication and possibly another indigestible layer and more medication. The laser drilling allows a aperture or a pattern of apertures to be drilled through the various layers. This permits the medication to be released in the stomach through the apertures. By varying the size and number of apertures the delay of the medication can be “metered”.
The non-contact laser process is perfectly suited for this task as the drilling can be accomplished at extremely high rates with an infinite number of aperture sizes and pattern variations. With the addition of a vision system, aperture quality can be controlled, mis-drilled tablets or capsules can be rejected-and all of this can be done on-the-fly.
Additionally, the laser reacts favorably with medication and their carrier materials during the drilling process.
Control Micro Systems has been an industry innovator in on-the-fly tablet drilling systems for pharmaceutical companies. Our experience with high speed, reliable on-the-fly systems makes us the best choice for drilling your tablets or capsules. |
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